Alternatives to Apical View in Predicting Fluid Responsiveness by Transthoracic Echocardiography: An Observational Study

Main Article Content

Haimeur Yassine
Aberouch Larbi
Tadili Jawad
Faroudy Mamoun
El Kettani Ali

Abstract

Introduction: Flow analysis in the apical view of transthoracic echocardiography is validated to assess fluid responsiveness at the bedside. Still, it is not always reachable, especially in mechanically ventilated patients and during surgery. We compared it to supra-sternal and sub-xiphoid views to evaluate their validity in assessing fluid responsiveness in critically ill patients.


Method: A cross-sectional prospective monocentric pilot study of three months duration has been led in the critical care unit for surgical emergencies of Ibn Sina University Hospital of Rabat (Morocco). We used the time-velocity index (VTI) and peak velocity variation (∆Vpeak) values correlation between the three acoustic windows as the main judgment criteria. Measurement of data was made in the Left Ventricle Outflow Tract (LVOT) in the 5-chamber apical view, Descending Thoracic Aorta (DTA) in the supra-sternal view, and Right Ventricle Outflow Tract (RVOT) in the sub-xiphoid view.


Results: There were 14 adult patients involved in the study, and the data presented are preliminary results. There was no significant difference in VTI and ∆Vpeak values between the three acoustic windows at each time of the study protocol, with a very high correlation for initial VTI value between 5-chamber apical view and supra-sternal view (r = 0.96, p < 0.001), and sub-xiphoid view (r = 0.86, p < 0.001). A very high correlation of initial ∆Vpeak value was also observed between the 5-chamber apical view and supra-sternal view (rho = 0.89, p < 0.001) and sub-xiphoid view (rho = 0.79, p < 0.001).


Discussion: Supra-sternal and sub-xiphoid views showed high potential to predict fluid responsiveness, but further data are needed to validate their use for this purpose in ICU and in operating room.

Article Details

Yassine, H., Larbi, A., Jawad, T., Mamoun, F., & Ali, E. K. (2025). Alternatives to Apical View in Predicting Fluid Responsiveness by Transthoracic Echocardiography: An Observational Study . Journal of Clinical Intensive Care and Medicine, 006–012. https://doi.org/10.29328/journal.jcicm.1001052
Observational Studies

Copyright (c) 2025 Yassine H, et al.

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Boyd JH, Forbes J, Nakada TA, Walley KR, Russell JA. Fluid resuscitation in septic shock: a positive fluid balance and elevated central venous pressure are associated with increased mortality. Crit Care Med. 2011;39(2):259–65. Available from: https://doi.org/10.1097/ccm.0b013e3181feeb15

Silva JM, de Oliveira AM, Nogueira FA, Vianna PM, Pereira Filho MC, Dias LF, et al. The effect of excess fluid balance on the mortality rate of surgical patients: a multicenter prospective study. Crit Care. 2013;17:R288. Available from: https://doi.org/10.1186/cc13151

National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials Network, Wiedemann HP, Wheeler AP, Bernard GR, Thompson BT, Hayden D, et al. Comparison of two fluid-management strategies in acute lung injury. N Engl J Med. 2006;354(24):2564–75. Available from: https://doi.org/10.1056/nejmoa062200

Cecconi M, De Backer D, Antonelli M, Beale R, Bakker J, Hofer C, et al. Consensus on circulatory shock and hemodynamic monitoring. Task force of the European Society of Intensive Care Medicine. Intensive Care Med. 2014;40(12):1795–815. Available from: https://doi.org/10.1007/s00134-014-3525-z

Monnet X, Marik PE, Teboul JL. Prediction of fluid responsiveness: an update. Ann Intensive Care. 2016;6:111. Available from: https://doi.org/10.1186/s13613-016-0216-7

Broch O, Renner J, Gruenewald M, Meybohm P, Höcker J, Schöttler J, et al. Variation of left ventricular outflow tract velocity and global end-diastolic volume index reliably predict fluid responsiveness in cardiac surgery patients. J Crit Care. 2012;27(3):325.e7–13. Available from: https://doi.org/10.1016/j.jcrc.2011.07.073

Desai N, Garry D. Assessing dynamic fluid-responsiveness using transthoracic echocardiography in intensive care. BJA Educ. 2018;18(7):218–26. Available from: https://doi.org/10.1016/j.bjae.2018.03.005

Schober P, Loer SA, Schwarte LA. Haemodynamic monitoring of critically ill patients with transoesophageal Doppler technology. Neth J Crit Care. 2010;14:388–94. Available from: https://doi.org/10.1213/ane.0b013e3181aa0af3

De Backer D, Heenen S, Piagnerelli M, Koch M, Vincent JL. Pulse pressure variations to predict fluid responsiveness: influence of tidal volume. Intensive Care Med. 2005;31(4):517–23. Available from: https://doi.org/10.1007/s00134-005-2586-4

Galderisi M, Henein MY, D'hooge J, Sicari R, Badano LP, Zamorano JL, et al. Recommendations of the European Association of Echocardiography. How to use echo-Doppler in clinical trials: different modalities for different purposes. Eur J Echocardiogr. 2011;12(5):339–53. Available from: https://doi.org/10.1093/ejechocard/jer051

Blanco P. Rationale for using the velocity–time integral and the minute distance for assessing the stroke volume and cardiac output in point-of-care settings. Ultrasound J. 2020;12:21. Available from: https://doi.org/10.1186/s13089-020-00170-x

Souto R, Melo WB, Freire CMV, Vilas Boas WW. Comparative study between suprasternal and apical windows: a user-friendly cardiac output measurement for the anesthesiologist. Braz J Anesthesiol. 2021:S0104-0014(21)00264-5. Available from: https://doi.org/10.1016/j.bjane.2021.02.063

Samra T, Deepak R, Jayant A, Saini V. The utility of limited trans-thoracic echocardiography in the stratification of pulse pressure variation: A feasibility study in major open abdominal surgery. Saudi J Anaesth. 2018;12(4):584–92. Available from: https://doi.org/10.4103/sja.sja_686_17

Cheong I, Otero Castro V, Brizuela M, Früchtenicht MF, Merlo PM, Tamagnone FM. Passive leg raising test to predict fluid responsiveness using the right ventricle outflow tract velocity-time integral through a subcostal view. J Ultrasound. 2022 Sep 21. Epub ahead of print. PMID: 36127570. Available from: https://doi.org/10.1007/s40477-022-00719-7