Abstract

Research Article

Immunocompromised patients with SARS-CoV-2 infection in intensive care units, outcome and mortality

Cynthia DENIS*, Hamid MERDJI, Mathieu BALDACINI, Maleka SCHENCK, Thierry ARTZNER, Yoann GRIMAUD, Thierry LAVIGNE, Ferhat MEZIANI, Vincent CASTELAIN, Raphaël CLERE-JEHL, Francis SCHNEIDER and Guillaume MOREL

Published: 17 August, 2021 | Volume 6 - Issue 1 | Pages: 021-025

Background: The new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak severely hit Northeastern France from March to May 2020. The massive arrival of SARS-CoV-2 positive patients in the intensive care units (ICU) raised the question of how immunocompromised patients would be affected. Therefore, we analyzed the clinical, biological and radiological features of 24 immunocompromised ICU patients with severe SAR-CoV-2 infection.

Results: The mortality rate was significantly higher for immunocompromised patients compared with other patients (41.7% versus 27.3%, respectively, p = 0.021). Mortality occurred in the first 2 weeks of intensive care, highlighting the possible interest in prolonged full-code managnement of these patients. Finally, patients with lymphoid malignancies appeared to be particularly affected, mostly with monoclonal gamma-pathology.

Conclusion: Mortality rate of SARS-CoV-2 acute respiratory syndrome in immuno-compromised patient is high. No treatment was associated with survival improvement. Prolonged full-code management is required for these patients.

Read Full Article HTML DOI: 10.29328/journal.jcicm.1001036 Cite this Article Read Full Article PDF

Keywords:

SARS-CoV-2; Critical care; Immunocompromised

References

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